Hair Loss

A New Mechanism to Explain Obesity-Induced Hair Loss. — Donovan Hair Clinic

A high fat diet caused stem cells to undergo abnormal differentiation. In other words, stem cells were forced to change their job title from potent stem cells to skin surface corneocytes or sebum secreting sebocytes. This change was permanent since these new cell types are not able to produce new hairs. Therefore, the abnormal differentiation of stem cells caused a permanent loss of a hair producing stem cell from the finite pool of stem cells.

Mice fed a high fat diet showed progressive hair follicle miniaturization and hair loss. The change was shown to occur relatively quickly and even four days of eating a high fat diet triggered hair follicle stem cells to initiate the process of changing into other cell types.

This study provides new mechanistic insights into a well accepted notion that obesity affects the hair.

Reference

Morinaga, H., Mohri, Y., Grachtchouk, M. et al. Obesity accelerates hair thinning by stem cell-centric converging mechanisms. Nature 595, 266–271 (2021).

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You can follow a few hair hygiene tips to make your hair less likely to fall out: Avoid hairstyles that pull on the hair - Avoid high-heat hair styling tools - Don't chemically treat or bleach your hair - Use a shampoo that's mild and suited for your hair - Use a soft brush made from natural fibers - Try low-level light therapy.

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