A high fat diet caused stem cells to undergo abnormal differentiation. In other words, stem cells were forced to change their job title from potent stem cells to skin surface corneocytes or sebum secreting sebocytes. This change was permanent since these new cell types are not able to produce new hairs. Therefore, the abnormal differentiation of stem cells caused a permanent loss of a hair producing stem cell from the finite pool of stem cells.
Mice fed a high fat diet showed progressive hair follicle miniaturization and hair loss. The change was shown to occur relatively quickly and even four days of eating a high fat diet triggered hair follicle stem cells to initiate the process of changing into other cell types.
This study provides new mechanistic insights into a well accepted notion that obesity affects the hair.
Morinaga, H., Mohri, Y., Grachtchouk, M. et al. Obesity accelerates hair thinning by stem cell-centric converging mechanisms. Nature 595, 266–271 (2021).
This blog is for information purposes only. The content is not intended as medical advice, diagnosis, or treatment. Should you have a medical or dermatological problem, please consult with your physician. None of the information or recommendations on this website should be interpreted as medical advice.
All product reviews, recommendations, and references are based on the author’s personal experience and impressions using the products. All views and opinions are the author’s own.
This blog post may contain affiliate links. An affiliate link means we may earn a commission if you click on a link and make a purchase, without any extra cost to you.
Please see our Disclaimer for more information.